Budesonide and Nasal Histamine Challenge

Abstract

The possible mode of action of the lately demonstrated steroid effect on the immediate type allergic reaction in humans was investigated. The influence of a topical steroid, budesonide, on the effects that released mediators have on the nasal mucosa was also studied. A nasal histamine challenge study was performed in a double-blind, cross-over fashion, a 1-wk pretreatment with budesonide or placebo preceding the challenge. Symptoms were recorded by symptom core and objectively via rhinomanometry. In contrast to a previous allergen challenge study, the steroid had minimal effect on the histamine-induced nasal symptoms. Other modes of steroid action must also be involved in the steroid effect on the immediate type allergic reaction.