Effect of various Electrolytes upon Thallium Intoxication

Abstract

Experiments on rats indicate that thallium acetate, given in doses that cause little renal damage and no nephrocalcinosis, induces intense and sometimes fatal renal calcification if either NaH2PO4 or Na2HPO4 is administered concurrently. The type of nephrocalcinosis produced under these conditions by the two sodium phosphates is essentially different. Equimolecular amounts of calcium acetate do not induce nephrocalcinosis following treatment with similar doses of thallium acetate, but certain sodium salts, particularly the acetate and citrate, unlike the chloride, are slightly effective in this respect.