A comparative account of the effects of betamethasone on mice infected with Plasmodium vinckei chabaudi and Plasmodium berghei yoelii
- 1 February 1974
- journal article
- research article
- Published by Cambridge University Press (CUP) in Parasitology
- Vol. 68 (1), 19-26
- https://doi.org/10.1017/s0031182000045339
Abstract
The malaria parasites, Plasmodium berghei yoelii and P. vinckei chabaudi, run comparable courses of infection in mice. When mice were treated with betamethasone infections with P. v. chabaudi were enhanced while those of P. b. yoelii were depressed. Antibody levels in betamethasone-treated mice infected with either P. b. yoelii or P. v. chabaudi were depressed to similar extents. The differences in parasitaemias in the two different infections are attributed to the suppression of reticulocyte production by betamethasone. P. b. yoelii preferentially invades reticulocytes and the patterns of parasitaemia follow the level of reticulocytes in the blood. P. v. chabaudi has no preference for reticulocytes and the pattern of parasitaemia is influenced by the depressed immunological response of the host.Keywords
This publication has 12 references indexed in Scilit:
- Multiple modes of action of cyclophosphamide on plasmodial infections in ratsTransactions of the Royal Society of Tropical Medicine and Hygiene, 1972
- Immunosuppression in Rodent MalariaThe American Journal of Tropical Medicine and Hygiene, 1971
- Acquired immunity toPlasmodium chabaudiin Swiss TO micePathogens and Global Health, 1970
- Immunological Aspects of Malaria InfectionAdvances in Immunology, 1969
- The effect of betamethasone on acquired immunity toPlasmodium vinckeiin micePathogens and Global Health, 1968
- Cortisone and Antimalarial Drug Activity Against Plasmodium BergheiThe Journal of Infectious Diseases, 1963
- STUDIES ON FACTORS WHICH CONDITION THE EFFECT OF CORTISONE ON ANTIBODY PRODUCTIONActa Pathologica Microbiologica Scandinavica, 1956
- Cortisone andPlasmodium BergheiInfection in RodentsPathogens and Global Health, 1954
- The effect of cortisone on Plasmodium berghei infectionsParasitology, 1954
- Cortisone and Plasmodium berghei Infection in MiceNature, 1952