At the conclusion of his article on Hodgkin's disease in the 1939 University of Wisconsin Symposium on Blood, Krumbhaar1 succinctly commented: "Thus we see that in general, the problems of Hodgkin's disease in the past generation remain the problems of today. We still do not know whether it is an infectious granuloma or a neoplasm, and, therefore, we are ignorant of its pathogenesis; we have no specific laboratory diagnostic test other than the biopsy examination. We have no means of predicting how long a given case will survive; and we have no specific form of treatment." It was with the hope of throwing some light on the two last-named factors that this study was undertaken. The review also included a careful search for clues as to a common predisposing factor or etiologic agent. However, the main question posed was: Are there any criteria for predicting the course and duration