THE PROBLEM OF PLACENTAL PERMEABILITY FOR THYROTROPHIN, PROPYLTHIOURACIL AND THYROXINE IN THE GUINEA PIG1
- 1 February 1952
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 50 (2), 218-225
- https://doi.org/10.1210/endo-50-2-218
Abstract
The thyroids and pituitaries of offspring from thyroidectomized female guinea pigs treated with thyrotropin during pregnancy did not differ in wt. from those of controls, nor was there any histologicai sign of stimulation of the fetal thyroid. Admn. of propylthiouracil during pregnancy causes hyperplasia of the fetal thyroid and pituitary which can be counteracted by the simultaneous admn. of thyroxine. Both the fetal thyroid and pituitary are suppressed in development when thyroxine alone is injd. into pregnant animals. The guinea pig placenta is impermeable to thyrotropin, but is permeable to both propylthiouracil and thyroxine.Keywords
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