Synthesis of shrimp red pigment-concentrating hormone analogs and their biological activity in locusts
- 12 January 2009
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 23 (1), 39-41
- https://doi.org/10.1111/j.1399-3011.1984.tb02689.x
Abstract
Two analogs of the red pigment-concentrating hormone (RPCH) were synthesized by the solid-phase method: [Thr6]-RPCH (I) and [Tyr4, Thr6]-RCPH (II). Analog I has the same amino acid composition as the 2nd adipokinetic hormone (AKH-II) isolated from locust corpora cardiaca. Bioasay for lipid-mobilizing activity in adult male locusts gave the following increases in hemolymph lipid content: AKH-I, 3.5; I, 2.4; II, 2.9. The biological response shown by I lends support to the conclusion that its sequence is that of the presumptive AKH-II. Replacement of Phe in position 4 by Tyr does not reduce the adipokinetic response.Keywords
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