PROSTAGLANDIN PRODUCTION BY MACROPHAGES AND THE EFFECT OF ANTI‐INFLAMMATORY DRUGS
Open Access
- 1 August 1978
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 63 (4), 635-642
- https://doi.org/10.1111/j.1476-5381.1978.tb17276.x
Abstract
1 Macrophages derived from peritoneal cavity inflammatory exudates of guinea-pigs produced substantial amounts of prostaglandin E2-like activity during in vitro culture, so providing the basis for an experimental model of prostaglandin production during inflammatory reactions. 2 Dose-related inhibition of prostaglandin biosynthesis was demonstrated by 16 acidic non-steroidal anti-inflammatory drugs. 3 Seven anti-inflammatory glucocorticosteroid preparations inhibited prostaglandin production in a dose-related manner. The relative potencies of dexamethasone, prednisolone and hydrocortisone were consistent with clinical anti-inflammatory ranking. Cortisone, however, failed to inhibit macrophage prostaglandin production. 4 Three other agents used in the treatment of inflammatory joint diseases were examined. Sodium aurothiomalate inhibited prostaglandin production, although higher concentrations were toxic to macrophages. D-Penicillamine did not affect macrophage prostaglandin production. Colchicine, in contrast, enhanced prostaglandin production at some concentrations. 5 The probable significance of macrophages as a source of prostaglandins, during inflammatory responses, is discussed.Keywords
This publication has 48 references indexed in Scilit:
- Hydrocortisone inhibits prostaglandin production by mouse fibrosarcoma cellsNature, 1975
- Corticosteroids inhibit prostaglandin production by rheumatoid synoviaNature, 1975
- Tissue gold levels after chrysotherapy.Annals Of The Rheumatic Diseases, 1974
- Leukocytes and prostaglandins in acute inflammationCellular and Molecular Life Sciences, 1974
- New Aspects of the Mode of Action of Nonsteroid Anti-Inflammatory DrugsAnnual Review of Pharmacology, 1974
- DA 2370 serum and synovial fluids concentrations in patients with rheumatoid arthritisCurrent Medical Research and Opinion, 1974
- Inhibition of prostaglandin synthesis in manBiochemical and Biophysical Research Communications, 1972
- Inhibition of Prostaglandin Biosynthesis by CorticosteroidsBMJ, 1972
- The Influence of Various Adjuvants on the Metabolism of Phospholipids in MacrophagesInternational Archives of Allergy and Immunology, 1969
- Simultaneous salicylate concentrations in synovial fluid and plasma in rheumatoid arthritisArthritis & Rheumatism, 1964