Urinary Excretion and Cerebrospinal Fluid Concentration of Cyclic Adenosine-3’,5’-monophosphate in Various Neurological Diseases

Abstract

Cerebrospinal fluid (CSF) concentration and urinary excretion of cyclic adenosine-3’,5’-monophosphate (cAMP) were measured by a radioimmunoassay method from 84 and 47 neurological patients, respectively. cAMP concentration in CSF showed great variation. The mean value of female patients was higher (p<0.02) than that of males. CSF concentration of cAMP of patients with old central lesion (including contusio cerebri, status post meningoencephalitidem, and atrophia cerebri) diagnosed at least 6 months earlier was lower (p<0.001) than that of all patients. No clear alterations in CSF concentration of cAMP were seen in other groups of diagnoses or in patients ingesting drugs known to influence the cAMP system in vitro. Urinary excretion of cAMP of hypertensive patients was higher (p<0.05) than that of normotensive ones. Our results demonstrate that there is no clear correlation between urinary excretion of cAMP and the neurological diseases studied or the drugs ingested. cAMP concentrations in CSF did not correlate to the urinary excretion of cAMP.