Characteristics and management of HIV-1-infected pregnant women enrolled in a randomised trial: differences between Europe and the USA
Open Access
- 20 June 2007
- journal article
- research article
- Published by Springer Nature in BMC Infectious Diseases
- Vol. 7 (1), 60
- https://doi.org/10.1186/1471-2334-7-60
Abstract
Rates of mother-to-child transmission of HIV-1 (MTCT) have historically been lower in European than in American cohort studies, possibly due to differences in population characteristics. The Pediatric AIDS Clinical Trials Group Protocol (PACTG) 316 trial evaluated the effectiveness of the addition of intrapartum/neonatal nevirapine in reducing MTCT in women already receiving antiretroviral prophylaxis. Participation of large numbers of pregnant HIV-infected women from the US and Western Europe enrolling in the same clinical trial provided the opportunity to identify and explore differences in their characteristics and in the use of non-study interventions to reduce MTCT.Keywords
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