Chlorinated Hydrocarbons in Human Bone Marrow of Healthy Individuals and Leukemia Patients
- 1 February 1996
- journal article
- research article
- Published by Taylor & Francis in Archives of environmental health
- Vol. 51 (1), 22-25
- https://doi.org/10.1080/00039896.1996.9935988
Abstract
In this pilot study, concentrations of chlorinated hydrocarbons in bone marrow were determined by capillary-column gas chromatography. Bone marrow was obtained from a total of 29 healthy adults and from patients with leukemia or lymphoma. The chlorinated hydrocarbons in adults that occurred in the highest concentrations were dichlorodiphenyltrichloroethane and its derivatives (mean = 129 mg/g DNA). Hexachlorobenzene, the hexachlorohexane isomers, and dieldrin were also found, but in reduced concentrations (i.e., mean concentrations: 49.5 mg/g DNA, 14.9 mg/g DNA, and 5.9 mg/g DNA, respectively). Patients who had leukemia and lymphoma did not have significantly increased concentrations of chlorinated hydrocarbons.Keywords
This publication has 13 references indexed in Scilit:
- Myeloid leukemias and myelodysplastic syndromes: chemical exposure, histologic subtype and cytogenetics in a case-control studyCancer Genetics and Cytogenetics, 1993
- Chlorinated hydrocarbons in the bone Marrow of children: Studies on their association with leukaemiaEuropean Journal of Pediatrics, 1992
- Morphologic, immunologic and cytogenetic studies in acute myeloid leukemia following occupational exposure to pesticides and organic solventsLeukemia Research, 1992
- Distinct cytogenetic and clinicopathologic features in acute myeloid leukemia after occupational exposure to pesticides and organic solventsCancer, 1992
- Comparison of the activity of topically applied pesticides and the herbicide 2,4-D in two short-term in vivo assays of genotoxicity in the mouseFundamental and Applied Toxicology, 1990
- Chlorinated hydrocarbons in fat tissue: Analyses of residues in healthy children, tumor patients, and malformed childrenArchives of Environmental Contamination and Toxicology, 1990
- Distribution and Elimination of 14C‐Hexachlorobenzene after Single Oral Exposure in the Male RatActa Pharmacologica et Toxicologica, 1983
- Rückstandsanalyse von Chlorkohlenwasserstoffen in Humanknochenmark durch hochauflösende Gas-Chromatographie mit Elektroneneinfang-DetektorAnalytical and Bioanalytical Chemistry, 1982
- Distribution and elimination of Hexachlorobenzene (Hcb) after single oral exposure in japanese quail (coturnix coturnix japonica)Journal of Toxicology and Environmental Health, 1981
- Column switching techniques in the liquid chromatographic analysis of organochlorine pesticides in milkJournal of Chromatography A, 1976