Gating of the polycystin ion channel signaling complex in neurons and kidney cells
Open Access
- 6 February 2004
- journal article
- fj express-summaries
- Published by Wiley in The FASEB Journal
- Vol. 18 (6), 740-742
- https://doi.org/10.1096/fj.03-0319fje
Abstract
Mutations in either polycystin-2 (PC2) or polycystin-1 (PC1) proteins cause severe, potentially lethal, kidney disorders and multiple extrarenal (including brain) disease phenotypes. PC2, a member of...Keywords
Funding Information
- National Institutes of Health
- Centre National de la Recherche Scientifique
This publication has 37 references indexed in Scilit:
- Polycystin-1 Activation of c-Jun N-terminal Kinase and AP-1 Is Mediated by Heterotrimeric G ProteinsJournal of Biological Chemistry, 2002
- Constitutive Activation of G-proteins by Polycystin-1 Is Antagonized by Polycystin-2Journal of Biological Chemistry, 2002
- Polycystin channels and kidney diseaseTrends in Pharmacological Sciences, 2001
- The genetics and physiology of polycystic kidney diseaseSeminars in Nephrology, 2001
- Molecular Genetics and Mechanism of Autosomal Dominant Polycystic Kidney DiseaseMolecular Genetics and Metabolism, 2000
- The Polycystic Kidney Disease 1 Gene Product Mediates Protein Kinase C α-dependent and c-Jun N-terminal Kinase-dependent Activation of the Transcription Factor AP-1Journal of Biological Chemistry, 1998
- Comparative analysis of the polycystic kidney disease 1 (PKD1) gene reveals an integral membrane glycoprotein with multiple evolutionary conserved domainsHuman Molecular Genetics, 1997
- PKD2 , a Gene for Polycystic Kidney Disease That Encodes an Integral Membrane ProteinScience, 1996
- The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domainsNature Genetics, 1995
- Autosomal Dominant Polycystic Kidney Disease—More Than a Renal DiseaseAmerican Journal of Kidney Diseases, 1990