Identification of a monoclonal antibody specific for a murine T3 polypeptide.
- 1 March 1987
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 84 (5), 1374-1378
- https://doi.org/10.1073/pnas.84.5.1374
Abstract
A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific for a 25-kDa protein component (T3-.epsilon.) of the antigen-specific T-cell receptor. It reacts with all mature T cells and can both activate and inhibit T-cell function. These results identify T3-.epsilon. as a cell surface protein involved in the transduction of activation signals.Keywords
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