The relationship between dietary intake, weight change, nitrogen balance, and protein turnover in man
Open Access
- 1 August 1977
- journal article
- research article
- Published by Elsevier in The American Journal of Clinical Nutrition
- Vol. 30 (8), 1345-1348
- https://doi.org/10.1093/ajcn/30.8.1345
Abstract
We have examined the relationships between protein turnover, protein synthesis, and protein breakdown and dietary intake, weight change, and nitrogen balance in children who were recovering and had recovered from severe protein-energy-malnutrition. Protein metabolism was measured by giving [15N]glycine and measuring the enrichment of urinary urea. The level of dietary protein did not affect protein metabolism. There were highly significant correlations between both protein flux and protein synthesis and the ad libitum dietary intake, nitrogen balance, and weight change. Over the range of dietary intake, 60 to 270 cal/kg per day, the protein synthesis rate increased 5-fold. Large changes in dietary intake resulted in small changes in protein breakdown, with breakdown being least on an inadequate intake. Changes in the rate of protein breakdown did not contribute to changes in nitrogen balance or body weight.Keywords
This publication has 6 references indexed in Scilit:
- Protein turnover in patients before and after elective orthopaedic operationsBritish Journal of Surgery, 1977
- The effect of protein deprivation and starvation on the rate of protein synthesis in tissues of the ratBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1975
- " CATABOLIC " LOSS OF BODY NITROGEN IN RESPONSE TO SURGERYThe Lancet, 1974
- Interrelated changes in host metabolism during generalized infectious illnessThe American Journal of Clinical Nutrition, 1972
- Growth Hormone Response During Sandfly FeverJournal of Clinical Endocrinology & Metabolism, 1968
- Insulin Response during Tularemia in ManDiabetes, 1967