Protein evolution on rugged landscapes.
- 1 August 1989
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 86 (16), 6191-6195
- https://doi.org/10.1073/pnas.86.16.6191
Abstract
We analyze a mathematical model of protein evoluation in which the evolutionary process is viewed as hill-climbing on a random fitness landscape. In studying the structure of such landscapes, we note that a large number of local optima exist, and we calculate the time and number of mutational changes until a protein gests trapped at a local optimum. Such a hill-climbing process may underlie the evolution of antibody molecules by somatic hypermutation.This publication has 18 references indexed in Scilit:
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