Quinidine-Digoxin Interaction

Abstract
Administration of quinidine with digoxin increased serum digoxin concentrations in 79 patients and five volunteers. In 38 patients on a constant glycoside maintenance dose, the addition of quinidine to digoxin therapy resulted in a mean 2.5-fold increase (from 0.98±0.37 to 2.47±0.71 ng per milliliter, mean ±1 S.D.) (P<0.001).