Complementary recessive 25-hydroxycholesterol-resistant somatic cell mutants - assay of 25-hydroxycholesterol binding activity
- 1 November 1982
- journal article
- research article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 113 (2), 314-319
- https://doi.org/10.1002/jcp.1041130220
Abstract
Complementation analysis of recessive 25-hydroxycholesterol-resistant mutants of the CHO-KI cell shows the existence of at least two complementation groups, one of which is missing a binding activity for 25-hydroxycholesterol. Both complementation groups are shown to be refractory to inhibition of cellular HMG-CoA reductase activity and in the inhibition of biosynthesis of this enzyme by 25-hydroxycholesterol.This publication has 31 references indexed in Scilit:
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