MUTUALLY TOLERANT HOST AND DONOR TYPE IMMUNOLOGICALLY COMPETENT CELLS IN MOUSE RADIATION CHIMERAS

Abstract

SUMMARY Data are presented which: (1) indicate that in 3 out of 11 long-lived LAF₁ (host)-C3H (donor marrow) radiation chimeras, both host and donor immunologically reactive cells co-exist in an apparent state of mutual tolerance; and (2) demonstrate the presence of immunologically competent cells of host origin in two A (host)-LAF₁ (donor marrow) radiation chimeras. The theoretical implications of these and other data are discussed.