Nerve growth factor increases activity of ornithine decarboxylase in superior cervical ganglia of young rats.
- 1 October 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (10), 4681-4684
- https://doi.org/10.1073/pnas.74.10.4681
Abstract
Nerve growth factor [NGF] produces a rapid increase in the activity of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) in superior cervical ganglia of young rats in vivo and in vitro. Maximum activity occurs 6-7 h after addition NGF. The NGF-mediated increase in ornithine decarboxylase activity in vitro can be prevented by addition of cycloheximide, actinomycin D or antibody to NGF. A number of other agents were tested for their ability to increase ornithine decarboxylase activity in the ganglia; only NGF, and, to a slight extent, insulin were able to raise the activity of the enzyme. High concentrations of dibutyryl cyclic AMP (10 mM) were able to mimic the effect of NGF.This publication has 18 references indexed in Scilit:
- Trans-synaptic regulation of tyrosine 3-mono-oxygenase biosynthesis in rat adrenal medullaBiochemical Pharmacology, 1977
- Induction of tyrosine hydroxylase synthesis in rat superior cervical ganglia in vitro by nerve growth factor and dexamethasoneBiochemical and Biophysical Research Communications, 1977
- THE DE NOVO SYNTHESIS OF TYROSINE HYDROXYLASE IN RAT SUPERIOR CERVICAL GANGLIA IN VITRO: THE EFFECT OF NERVE GROWTH FACTORJournal of Neurochemistry, 1977
- NERVE GROWTH FACTOR AND THE ACTIVITY OF TYROSINE HYDROXYLASE IN ORGAN CULTURES OF RAT SUPERIOR CERVICAL GANGLIAJournal of Neurochemistry, 1977
- Differences in sensitivity to nerve growth factor of axon formation and tyrosine hydroxylase induction in cultured sympathetic neuronsNeuroscience, 1976
- PURIFICATION OF NERVE GROWTH FACTOR ANTIBODIES BY AFFINITY CHROMATOGRAPHYJournal of Neurochemistry, 1976
- 1,4-Diaminobutane (Putrescine), Spermidine, and SpermineAnnual Review of Biochemistry, 1976
- Effect of cyclic nucleotides on activity of cyclic 3′,5′-adenosine monophosphate phosphodiesteraseBiochemical Pharmacology, 1973
- Selective Induction by Nerve Growth Factor of Tyrosine Hydroxylase and Dopamine-β-Hydroxylase in the Rat Superior Cervical GangliaProceedings of the National Academy of Sciences, 1971
- THE NERVE GROWTH FACTOR: PURIFICATION AS A 30,000-MOLECULAR-WEIGHT PROTEINProceedings of the National Academy of Sciences, 1969