Molecular anatomy of the human glucose 6‐phosphate dehydrogenase core promoter
Open Access
- 23 October 1998
- journal article
- Published by Wiley in FEBS Letters
- Vol. 437 (3), 313-318
- https://doi.org/10.1016/s0014-5793(98)01259-9
Abstract
The gene encoding glucose 6‐phosphate dehydrogenase (G6PD), which plays a pivotal role in cell defense against oxidative stress, is ubiquitously expressed at widely different levels in various tissues; moreover, G6PD expression is regulated by a number of stimuli. In this study we have analyzed the molecular anatomy of the G6PD core promoter. Our results indicate that the G6PD promoter is more complex than previously assumed; G6PD expression is under the control of several elements that are all required for correct promoter functioning and, furthermore, a still unidentified mammalian specific factor is needed.Keywords
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