Progress in the Clinical Use of 3-(Ortho-Toloxy)-1, 2-Propanediol (Mephenesin) in Neurologic Disorders

Abstract

THE distress of many motor disorders is produced by exaggerated stretch reflexes (spasticity), excessive resistance to passive movement (rigidity) or abnormal involuntary movement of central origin (hyperkinesia).To be satisfactory, a therapeutic agent must be easy to administer, preferably orally, effective in prolonged administration and devoid of untoward side effects. Specifically, it should depress abnormal motor activity without impairing consciousness, coordination or normal motor functions. Numerous agents used on this service and elsewhere have failed in one or more respects. Parpanit,¹ Prostigmine and intravenous injection of procaine have been ineffective. Though the belladonna alkaloids have been helpful in selected cases . . .