H‐2 RESTRICTION PATTERN OF SECONDARY INFLUENZA VIRUS‐IMMUNE CYTOLYTIC T CELLS

Abstract

Summary: Stimulation of murine spleen lymphocytes of the H‐2^d and H‐2^q haplotype with influenza A/WSN virus results in the generation of T‐effector lymphocytes which lyse infected H‐2^b target cells in addition to infected H‐2^d target cells. Cross‐reactive lysis of infected H‐2^d and H‐2^b target cells is due to the action of single Tc clones as shown by adsorption on macrophages and limiting dilution assay.