This paper examines trends in residential segregation for blacks, Hispanics, and Asians in 60 SMSAs between 1970 and 1980 using data taken from the 1970 Fourth Count Summary tapes and the 1980 Summary Tape File 4. Segregation was measured using dissimilarity and exposure indices. Black segregation from Anglos declined in some smaller SMSAs in the south and west, but in large urban areas in the northeastern and north central states there was little change; in these areas blacks remained spatially isolated and highly segregated. The level of black-Anglo segregation was not strongly related to socioeconomic status or level of suburbanization. Hispanic segregation was markedly below that of blacks, but increased substantially in some urban areas that experienced Hispanic immigration and population growth over the decade. The level of Hispanic segregation was highly related to indicators of socioeconomic status, acculturation, and suburbanization. Asian segregation was everywhere quite low. During the 1970s the spatial isolation of Asians increased slightly, while dissimilarity from Anglos decreased. Results were interpreted to suggest that Asian enclaves were beginning to form in many U.S. metropolitan areas around 1980.