Acetaldehyde-Dependent Changes in Hemoglobin and Oxygen Affinity of Human Erythrocytes
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Hemoglobin
- Vol. 5 (3), 241-250
- https://doi.org/10.3109/03630268108997548
Abstract
In the presence of (the ethanol metabolite) acetaldehyde, metabolizing human erythrocytes accumulate an altered Hb product showing chromatographic similarity to Hb AIa or AIb. The adduct is stable to overnight dialysis with an intracellular half-life of about 5.5 days. Adduct formation is accompanied by proportional changes in cell oxygen affinity (decrease in P50 or 3 mm Hg/mM adduct). Little unaltered Hb remains after overnight incubation in 15 mM acetaldehyde, with significant adduct formation and marked reduction of cell ATP occurring after prolonged incubation in as little as 0.5 mM acetaldehyde.This publication has 19 references indexed in Scilit:
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