GDP does not support activation of adenylate cyclase nor ADP‐ribosylation of a guanine nucleotide binding protein by cholera toxin
Open Access
- 8 August 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 159 (1-2), 75-78
- https://doi.org/10.1016/0014-5793(83)80419-0
Abstract
The actions of cholera toxin (i.e., activation of adenylate cyclase and ADP‐ribosylation of a guanine nucleotide binding protein in purified membranes fronm rat liver) were GTP dependent. Neither of these actions of cholera toxin was reproduced with GDP. Simultaneous addition of ATP and MgCl2 along with GDP allowed cholera toxin to exert these actions. The role of GDP in adenylate cyclase regulation was discussed.Keywords
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