The inj. of estrone crystals suspended in water is superior to the inj. of similar quantities of estrone crystals suspended in oil or estrone in oil soln. in producing relief of menopausal symptoms and in prolonging the period of relief following cessation of injns. The inj. of estrone crystals in water is considered equivalent to implanting estrone crystals directly into the tissues, without necessitating the special technic required for implantation. Another advantage to the use of aq. suspensions of estrone is the freedom from possible sensitivity reaction to the oils which are usually used as vehicles for estrogens.