A Practical O2-Oxidation of Functionalized Alcohols Producing Carboxylic Acids Catalyzed by the Pd–C/Pb(OAc)2 System
- 1 May 1993
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 66 (5), 1511-1515
- https://doi.org/10.1246/bcsj.66.1511
Abstract
The Pd–C/Pb(OAc)2 system catalyzes selective O2-oxidation of ArCH(R)CH2OH to ArCH(R)COOH (useful intermediates for drug synthesis) in high yields without contamination of ArCOOH. The turnover number (substrate/Pd) is improved to 85 and >1800 by recycling the catalyst and using a special reactor, respectively. Alkanols are also efficiently oxidized to alkanoic acids by the title catalyst system.Keywords
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