Does the combination with handgrip increase the sensitivity of dipyridamole‐echocardiography test?

Abstract

The aim of this study was to assess the possibility of increasing the sensitivity of dipyridamoleechocardiography testing (DET:2‐D echo monitoring during dipyridamole infusion) by combining this procedure with handgrip testing. Dipyridamole‐handgrip test (DHT) was therefore performed in 24 patients with rest/effort angina, negative DET, and negative handgrip‐echo (without dipyridamole pretreatment). DHT consisted of 4.5 min of sustained 25% maximum grip strength, started 4 min after the end of dipyridamole infusion (0.56 mg/kg for 4 min). Interpretable studies were obtained in all patients. Of the 24 patients tested (10 without and 14 with significant coronary artery disease, CAD), only one CAD patient had a positive DHT, which indicates an increased sensitivity of 7% versus DET alone. In conclusion, DHT is feasible in all patients and—if compared to DET—has the same specificity. However, in spite of the theoretical premises, it provides only a modest step up in sensitivity.