Interacting enzyme systems at steady state: further Monte Carlo calculations on two-state molecules.

Abstract

Monte Carlo calculations were made on a 10 .times. 10 lattice of 2-state, steady-state enzyme molecules in 2 special cases for which the Bragg-Williams (mean field) approximation had earlier produced some very interesting phase-transition properties. The Monte Carlo results proved to be similar to Bragg-Williams in some respects but not in others. The discrepancies are attributed primarily to: inadequate treatment by Bragg-Williams of strong negative cooperativity; and the finite size of the 10 .times. 10 lattice used in the exact calculations.