Mechanism of Action of Inhibin
- 1 April 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Biology of Reproduction
- Vol. 24 (3), 541-550
- https://doi.org/10.1095/biolreprod24.3.541
Abstract
Cultured anterior pituitary cells have been used to study the mechanism of action of ovine testicular inhibin proteins. Exposure of cells to inhibin for 48 or 72 h produced dose-dependent inhibition of FSH but not LH content, whereas shorter incubation times with inhibin did not reduce FSH. These changes were the result of inhibition of FSH production by the cell cultures. Despite the time delay before content was suppressed, FSH- and LH-stimulated release (10 nM LHRH) and FSH spontaneous release (no LHRH) were significantly reduced within 6 h of incubation with inhibin. This effect on release was not observed with a more active semipurified inhibin fraction derived from rete testis fluid.This publication has 4 references indexed in Scilit:
- A Simple and Rapid in Vitro Bioassay for Inhibin*Endocrinology, 1980
- PURIFICATION OF "INHIBIN" FROM HUMAN OVARIAN FOLLICULAR FLUIDActa Endocrinologica, 1979
- Partial Characterization of FSH Suppressing Activity (Foilicuiostatin) in Porcine Foiiicuiar Fluid Using the Metestrous Rat as an in vivo Bioassay ModelBiology of Reproduction, 1978
- IMMUNOCYTOCHEMICAL EVIDENCE THAT LUTEINIZING HORMONE (LH) AND FOLLICLE STIMULATING HORMONE (FSH) ARE PRESENT IN THE SAME CELL TYPE IN THE RHESUS MONKEY PITUITARY GLAND1Endocrinology, 1976