Heroin "Overdose" Death: Contribution of Drug-Associated Environmental Cues
- 23 April 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 216 (4544), 436-437
- https://doi.org/10.1126/science.7200260
Abstract
A model of "overdose" deaths among heroin addicts is proposed which emphasizes recent findings concerning the contribution of drug-associated environmental cues to drug tolerance. Results of animal experiments performed to evaluate this model suggest that conditioned drug-anticipatory responses, in addition to pharmacological factors, affect heroin-induced mortality.This publication has 22 references indexed in Scilit:
- Morphine tolerance in rats: Congruence with a Pavlovian paradigm.Journal of Comparative and Physiological Psychology, 1981
- Conditioned increases in locomotor activity produced with morphine as an unconditioned stimulus, and the relation of conditioning to acute morphine effect and tolerance.Journal of Comparative and Physiological Psychology, 1981
- Effects of Pavlovian conditioning and MIF-I on the development of morphine tolerance in ratsPharmacology Biochemistry and Behavior, 1980
- Evidence for conditioned tolerance of the tail flick reflexBehavioral and Neural Biology, 1980
- Challenging Some “Common Wisdom” on Drug AbuseInternational Journal of the Addictions, 1980
- Modulation of tolerance to the lethal effect of morphine by extinctionBehavioral and Neural Biology, 1979
- Tolerance to the hyperthermic effect of morphine in the rat is a learned response.Journal of Comparative and Physiological Psychology, 1978
- Morphine Analgesic Tolerance: Its Situation Specificity Supports a Pavlovian Conditioning ModelScience, 1976
- A technique for long-term blood sampling or intravenous infusion in the freely moving ratBiochemical Medicine, 1975
- Death from HeroinScience, 1970