Antigen-induced co-capping of IgM and IgD-like receptors on murine B cells.

Abstract

Double fluorescence studies indicated that most mature lymphocytes of 11-52 wk old mice possess IgM [immunoglobulin M] and IgD-like surface Ig, while spleen cells from neonatal mice possess surface IgM only. These molecules cap independently with class-specific antisera, but co-cap when capping is induced by antigen. The 2 H chains on individual lymphocytes apparently possess similar or identical antigen-combining sites.