Polymorphism of 5HT2A serotonin receptor gene is implicated in smoking addiction
- 22 March 2004
- journal article
- research article
- Published by Wiley in American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics
- Vol. 128B (1), 90-93
- https://doi.org/10.1002/ajmg.b.30004
Abstract
Smoking behavior is influenced by genetic factors. Polymorphisms affecting the dopaminergic system have been linked to smoking habits. The aim of this study was to investigate if the T102C polymorphism of the 5-HT2A receptor gene is related to tobacco use, since this receptor modulates the mesolimbic dopamine system and the C allele is associated with reduced receptor gene expression. A sample of 625 subjects were genotyped and classified according to their smoking behavior (never, former, or current smokers). We found differences in the distribution of the genotypes when the current smokers were compared with the never + former smokers, suggesting that T102C polymorphism is associated with maintenance, but not with initiation of the smoking habit. The CC genotype was more frequent in the current smokers than in the never + former smokers (χ2 = 6.825, P = 0.03). The odds ratio of being a current smoker with a CC genotype was 1.63, 95% CI 1.06–2.51.Keywords
This publication has 17 references indexed in Scilit:
- Problems of reporting genetic associations with complex outcomesThe Lancet, 2003
- Color and genomic ancestry in BraziliansProceedings of the National Academy of Sciences, 2002
- Reporting, Appraising, and Integrating Data on Genotype Prevalence and Gene-Disease AssociationsAmerican Journal of Epidemiology, 2002
- Tryptophan hydroxylase gene variant and smoking behaviorAmerican Journal of Medical Genetics, 2001
- Polymorphisms in genes involved in neurotransmission in relation to smokingEuropean Journal of Pharmacology, 2000
- The Ancestry of Brazilian mtDNA LineagesAmerican Journal of Human Genetics, 2000
- Addiction, Dopamine, and the Molecular Mechanisms of MemoryNeuron, 2000
- Reciprocal autoreceptor and heteroreceptor control of serotonergic, dopaminergic and noradrenergic transmission in the frontal cortex: relevance to the actions of antidepressant agentsJournal of Psychopharmacology, 2000
- A population-based twin study in women of smoking initiation and nicotine dependencePsychological Medicine, 1999
- The Fagerström Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance QuestionnaireBritish Journal of Addiction, 1991