Induction of chronic polyarthritis in rabbits by hyperimmunization with Escherichia Coli. I. Pathologic and serologic features in two breeds of rabbits
Open Access
- 30 April 1985
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 28 (5), 522-528
- https://doi.org/10.1002/art.1780280510
Abstract
Hyperimmunization of 147 rabbits (outbred Japanese white rabbits and New Zealand white [NZW] rabbits bred in a closed colony) with heat-killed Escherichia coli 0:14 in Freund's incomplete adjuvant resulted in the animals developing a chronic polyarthritis resembling rheumatoid arthritis (RA). While both Japanese white and NZW rabbits showed a high incidence of the induced arthritis, a higher proportion of NZW rabbits developed the disease, suggesting that genetic influence is important in the development of RA-like illness. This experimental model may be useful for the study of RA.This publication has 21 references indexed in Scilit:
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