Hippocampus: A Target for Estrogen Action in Mammalian Brain
- 1 July 1989
- journal article
- research article
- Published by The Endocrine Society in Molecular Endocrinology
- Vol. 3 (7), 1165-1170
- https://doi.org/10.1210/mend-3-7-1165
Abstract
An analysis of the distribution of estrogen receptor (ER) via immunoenzymatic assay in the brain of ovariectomized rats reveals the presence of large amounts of ER-like immunoreactive material in the cytosol of the hippocampus: a brian area described to contain little estrogen-binding activity. The protein detected in the hippocampus by the specific antibody is indistinguishable from the rat ER in its response to hormonal treatments and in its electrophoretic mobility. The presence of elevated amounts of ER in such an important part of the limbic system creates new possibilities for interpreting the role played by this sex hormone in the central nervous system of rat.This publication has 15 references indexed in Scilit:
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