Vitamin K Induced Prothrombin Formation: Antagonism by Actinomycin D
- 28 August 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 145 (3635), 926-928
- https://doi.org/10.1126/science.145.3635.926
Abstract
Actinomycin D inhibits vitamin K induced formation of prothrombin in chicks deficient in vitamin K. The administration of actinomycin in doses which inhibit prothrombin formation also inhibits synthesis in the liver of RNA from adenosine triphosphate as detected with adenine-8-C14. The results are consistent with a genetic action of vitamin K in inducing RNA formation for the synthesis of clotting proteinsKeywords
This publication has 9 references indexed in Scilit:
- Vitamin K Deficiency and Oxidative PhosphorylationJournal of Nutrition, 1963
- Effect of Actinomycin D on Cellular Nucleic Acid Synthesis and Virus ProductionScience, 1961
- Genetic regulatory mechanisms in the synthesis of proteinsJournal of Molecular Biology, 1961
- Relationship between prothrombin time and oxidative phosphorylation in chick liver mitochondriaArchives of Biochemistry and Biophysics, 1959
- On Inhibition of Vit. K Activity by Sulfaquinoxaline in ChicksExperimental Biology and Medicine, 1957
- CONGENITAL HYPOPROTHROMBINEMIC STATESArchives of Internal Medicine, 1955
- Oxydative phosphorylierung und vitamin K MangelBiochimica et Biophysica Acta, 1954
- THE NATURE OF THE HEMOERHAGIC DISEASE OF THE NEWBORN. DELAYED RESTORATION OF THE PROTHROMBIN LEVELThe American Journal of the Medical Sciences, 1940