Dual Antibody Response to Coxsackie and Poliomyelitis Viruses in Patients with Paralytic Poliomyelitis.

Abstract

Both poliomyelitis virus and Coxsackie virus (C virus) were isolated from the acute phase stools of several paralytic patients during an epidemic of poliomyelitis which occurred in Easton, Pa., in 1949. In 2 such cases, neutralizing antibody tests were carried out with acute and convalescent serum reacting with a suspension of virus obtained directly from acute phase stools. Both patients responded to their illness by simulataneously developing antibodies both to poliomyelitis virus and to C virus.