Evidence Justifying a High Fluid Intake in Treatment of Nephrolithiasis

Abstract

The effect of urinary dilution on the crystallization of calcium salts was quantitatively assessed. Urinary dilution was achieved in vitro (1 to 2 l/d (day)) by addition of water to urine from 6 patients with renal stones and 2 normal subjects, and in vivo (1.023 to 2.383 l/d) by an increased ingestion of distilled water in 4 patients with nephrolithiasis and 3 normal subjects. Both forms of urinary dilution significantly reduced the urinary activity product ratio (state of saturation) of calcium phosphate (brushite), calcium oxalate and monosodium urate. The formation product ratio (limit of metastability or minimum supersaturation needed to elicit spontaneous nucleation) of calcium oxalate significantly increased, although that for brushite did not change significantly. There was a reduced propensity for crystallization of calcium salts. The results provide objective evidence for the beneficial role of an increased fluid intake in the management of nephrolithiasis.