IMMUNOLOGICAL REACTIVITY BETWEEN CHIMERIC CATTLE TWINS

Abstract

The response of normal single-born calves to the s.c. injection of allogeneic lymphocytes and that of chimeric calves to allogeneic and cotwin cells were studied. Allogeneic cells produced local dermal swelling along with an efflux of blast cells and specific cytolytic antibody in the regional lymph. Injection of cotwin lymphocytes into chimeric calves failed to produce responses in excess of those of controls. There was little indication of specific reduction in responsiveness of the lymphocytes of normal calves following challenge with allogeneic cells.