A Mutant Form of JAB/SOCS1 Augments the Cytokine-induced JAK/STAT Pathway by Accelerating Degradation of Wild-type JAB/CIS Family Proteins through the SOCS-box
Open Access
- 1 November 2001
- journal article
- Published by Elsevier
- Vol. 276 (44), 40746-40754
- https://doi.org/10.1074/jbc.m106139200
Abstract
No abstract availableKeywords
This publication has 33 references indexed in Scilit:
- The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2Journal of Biological Chemistry, 2001
- CIS3/SOCS-3 Suppresses Erythropoietin (EPO) Signaling by Binding the EPO Receptor and JAK2Journal of Biological Chemistry, 2000
- Negative Regulation of Cytokine Signaling PathwaysAnnual Review of Immunology, 2000
- SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this CytokineCell, 1999
- Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin LigaseScience, 1999
- The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat familiesGenes & Development, 1998
- CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cellsOncogene, 1998
- Cloning and Characterization of Novel CIS Family GenesBiochemical and Biophysical Research Communications, 1997
- STATs and Gene RegulationScience, 1997
- Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin AGastroenterology, 1996