Exceptionally easy isomerization of acetylenic alcohols with potassium 3-aminopropylamide. A new, high yield synthesis of functionally differentiated αω-difunctional structures

Abstract

Potassium 3-aminopropylamide, readily prepared in situ from KH and 3-aminopropylamine, effects rapid, multipositional isomerization of the triple bond in prop-2-ynylic and other acetylenic alcohols to the chain terminus remote from the hydroxy function, within minutes at 0–20 °C.