Expression of HLA‐DR and common acute lymphoblastic leukemia antigens on glioma cells

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Abstract
The expression on several established human glioma cell lines of two well‐defined differentiation antigens, HLA‐DR and the common acute lymphoblastic leukemia antigen (CALLA) has been demonstrated. Rabbit anti‐CALLA antiserum and monoclonal anti‐la antibodies specifically lysed glioma cells in the presence of complement. Absorption of anti‐CALLA antiserum and anti‐Ia antibodies by glioma cells abolished their cytotoxicity against blasts isolated from a common acute lymphoblastic leukemia. Immunoprecipitation of solubilized glioma cells by monoclonal anti‐Ia antibodies revealed two polypeptide chains of 28 and 33 kDa, whereas the anti‐CALLA antiserum precipitated a single polypeptide chain of 100 kDa.