Parallel secretion of endogenous 5‐hydroxytryptamine and histamine from mast cells stimulated by vasoactive peptides and compound 48/80
Open Access
- 1 February 1984
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 81 (2), 227-229
- https://doi.org/10.1111/j.1476-5381.1984.tb10069.x
Abstract
The peptides, neurotensin, substance P, somatostatin, and bombesin, several analogues and fragments of neurotensin and compound 48/80, all caused the secretion of both endogenous 5-hydroxytryptamine (5-HT) and histamine. There was no differential effect of any of the secretagogues tested on the secretion of 5-HT and histamine. Amitriptyline prevented the secretion of histamine in response to stimulation by neurotensin, substance P, somatostatin or compound 48/80 but was without effect on the secretion of endogenous 5-HT.Keywords
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