The effects of oxygen concentration on porphyrin biosynthesis in chicken-erythrocyte preparations
- 1 January 1964
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 90 (1), 66-69
- https://doi.org/10.1042/bj0900066
Abstract
The effects of O2 concentration on porphyrin biosynthesis from -aminolevulinic acid and porphobilinogen were studied in whole hemolysates of chicken erythrocytes and in supernatants from these preparations. These studies show that concentrations of O2 higher than 5-7% (v/v) inhibit the conversion of porphobilinogen into uroporphyrinogen. This inhibition can be reversed by lowering the concentration of O2. The stability of uro-, copro- and protoporphy-rins to high concentrations of O2 was demonstrated.This publication has 13 references indexed in Scilit:
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