Intestinal blood flow during perfusion of the jejunum with hypertonic glucose in dogs

Abstract

Although it is well known that the infusion of the jejunum with hypertonic glucose solutions results in an increased intestinal blood flow, it is not known whether the effect is local or generalized in the gastrointestinal tract. Blood flow to a loop of jejunum in anesthetized dogs was measured by the Xe-133 clearance method during perfusion with 5% and 25% glucose solutions. The regional distribution of blood flow in the jejunum during perfusion was also measured using microspheres labeled with 2 different isotopes, 85Sr and 46Sc. With the 133Xe clearance method, there was no significant increase in blood flow during perfusion with 5% glucose, but a highly significant increase with 25% glucose. Distribution of microspheres showed that the blood flow to the gastrointestinal tract increased only in that part of the jejunum perfused with hypertonic glucose.