Physiology of the Secretion of Acid, Pepsin, Sulfated Polysaccharides and Glycoproteins by the Dog Fundic Mucosa

Abstract

The secretion of acid, pepsin, chondroitin sulfate and glycoproteins from mucus have been studied in four Heidenhain pouch dogs, under basal condition and during stimulation with histamine, a gastrin- like pentapeptide and a cholinergic drug. Histamine and the gastrin analogue stimulate acid and, to a lesser extent, pepsin secretion, and they inhibit mucus secretion; cholinergic stimulation increases the output of acid, chondroitin sulfate, pepsin and glycoproteins of the mucus. No qualitative changes in the secretion of peptic or mucous cells are observed.