Synthesis of Isothiocyanates by Reaction of Amides with Carbon Disulfide in the Presence of Solid Potassium Carbonate/Sodium Hydroxide Mixture

Abstract

Readily available N-monosubstituted trifluoroacetamides are transformed into isothiocyanates in good yield by reaction, at room temperature, with carbon disulfide in acetonitrile in the presence of anhydrous sodium hydroxide/potassium carbonate basic mixture.