TESTING OF 21 ENVIRONMENTAL AROMATIC-AMINES OR DERIVATIVES FOR LONG-TERM TOXICITY OR CARCINOGENICITY

Abstract

Aromatic amines or derivatives (21) were tested for long-term toxicity by dietary administration to male Charles River rats and male and female HaM/ICR mice. 2,4-Toluenediamine, o-phenylenediamine, o-toluidine, 2,4,6-trimethylaniline, 2,4,5-trimethylaniline, 2,5-xylidine and 1-chloro-2-nitrobenzene led to tumors in 1 or more tissues in all 3 of these animal models. p-Toluidine, 4-chloro-o-toluidine and 1-chloro-4-nitrobenzene had varying degrees of activity in male and female mice only. 4-Chloro-4''-aminodiphenyl ether affected male rats and female mice but there was no consistent dose response. 2,5-Dimethoxy-4''aminostilbene led to many tumors in male rats but had only a questionable action in male mice. The effect of 3,3'',4,4''-tetraaminobiphenyl in male rats was borderline; in the mice only males showed any response. In male mice 2,4,6-trichloroaniline had a fair degree of activity; tetrafluoro-m-phenylenediamine was somewhat less effective, and m-toluidine had only questionable activity. 2,4-Xylidine increased lung tumors in female mice at the higher dose only. Inactive compounds included m-phenylenediamine, 2,4-dinitrochlorobenzene, benzoguanamine and dicyclopentadiene dioxide. 2,4,6-Trimethylaniline led to cirrhosis of the liver in rats only.