GLUCOSE UTILIZATION AND INSULIN RESPONSIVENESS OF LEUCOCYTES IN DIABETES
- 1 July 1962
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 40 (7), 899-903
- https://doi.org/10.1139/o62-101
Abstract
Measurements were made of the uptake of glucose by leucocytes obtained from normal and diabetic subjects, on incubation in plasma and in synthetic media, with and without insulin. Cells of diabetics in bicarbonate medium showed an uptake of glucose which was lower than that of cells from non-diabetics. In plasma and bicarbonate medium they showed a decreased response to insulin. These results are compatible with prior findings of decreased glucose utilization and decreased insulin responsiveness in human diabetes of the maturity-onset type.Keywords
This publication has 5 references indexed in Scilit:
- Two Identical Embden-Meyerhof Enzyme Systems in Normal Rat Diaphragms Differing in Cytological Location and Response to InsulinJournal of Biological Chemistry, 1959
- Regulation of glucose uptake by muscle. 1. The effects of insulin, anaerobiosis and cell poisons on the uptake of glucose and release of potassium by isolated rat diaphragmBiochemical Journal, 1958
- Regulation of the uptake of glucose by the isolated rat diaphragmBiochimica et Biophysica Acta, 1957
- Glucose Utilization and Lactate Production by Leucocytes of Patients with Diabetes Mellitus.Experimental Biology and Medicine, 1957
- THE INFLUENCE OF GLUCOSE, FRUCTOSE, AND INSULIN ON THE METABOLISM OF LEUKOCYTES OF HEALTHY AND DIABETIC SUBJECTS 12JCI Insight, 1953