A New Antifertility Factor (A Preliminary Report)

Abstract

The author works on the hypothesis that phosphorylated hesperidin would inhibit hyaluronidase. Phosphorylated hesperidin, was found to be non-toxic to animals and to inhibit fertility as long as administered, but not after treatment ceased. Phosphorylated hesperidin (5 mg. daily per kg. body wt.; 40% with breakfast, 20% with lunch, and 40% with dinner) was then administered orally to both partners of 300 married couples of various ages, selected on a basis of easy prior impregnation, normal delivery, and desire for more children. Level of concn. in the blood is an important factor, and a single daily dose will not maintain saturation. No toxic or allergic reactions were found, even with 25 times the daily dose for 1[mu]-50 days. 10 consecutive days of use by both partners are necessary before antifertility action can be assured. Of the 300 couples, the antifertility action was complete except for 2 couples, who admitted lapses of 7 and 40 days, respectively, in their routine. All other couples who terminated fertility control did so voluntarily to have a wanted child; of these 298 couples, 41% of the wives have had a succeeding pregnancy and 32.3% were pregnant at time of writing. Babies were all healthy, normal specimens.