Nitric oxide is involved in heat‐induced HSP70 accumulation
- 21 August 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 370 (3), 159-162
- https://doi.org/10.1016/0014-5793(95)00801-f
Abstract
Heat shock potentiated the nitric oxide production (EPR assay) in the liver, kidney, heart, spleen, intestine, and brain. The heat shock-induced sharp transient increase in the rate of nitric oxide production preceded the accumulation of heat shock proteins (HSP70) (Western blot analysis) as measured in the heart and liver. In all organs the nitric oxide formation was completely blocked by the NO-synthase inhibitor Nω-nitro-L-arginine (L-NNA). L-NNA also markedly attenuated the heat shock-induced accumulation of HSP70. The results suggests that nitric oxide is involved in the heat shock-induced activation of HSP70 synthesis.Keywords
This publication has 16 references indexed in Scilit:
- NITRIC OXIDE: A Physiologic Messenger MoleculeAnnual Review of Biochemistry, 1994
- The relationship between l-arginine-dependent nitric oxide synthesis, nitrite release and dinitrosyl-iron complex formation by activated macrophagesBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1993
- Expression of different members of heat shock protein 70 gene family in liver and hepatomasHepatology, 1989
- Ischemia induces changes in the level of mRNAs coding for stress protein 71 and creatine kinase M.Circulation Research, 1988
- Synthesis of stress proteins in rat cardiac myocytes 2-4 days after imposition of hemodynamic overload.JCI Insight, 1988
- Cellular and biochemical events in mammalian cells during and after recovery from physiological stress.The Journal of cell biology, 1986
- Cultured human neural cells accumulate a heat-shock protein during acute herpes simplex virus infectionNeuroscience Letters, 1985
- Hypothalamic epinephrine is released into hypophysial portal blood during stressBrain Research, 1985
- Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycolurilBiochemical and Biophysical Research Communications, 1978
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970